Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50258739
Substrate
n/a
Meas. Tech.
ChEBML_1690669
IC50
619±n/a nM
Citation
 Nguyen, T; German, N; Decker, AM; Langston, TL; Gamage, TF; Farquhar, CE; Li, JX; Wiley, JL; Thomas, BF; Zhang, Y Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution. J Med Chem 60:7410-7424 (2017) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CNR2_MOUSE | Cannabinoid CB2 receptor | Cannabinoid receptor | Cannabinoid receptor 2 | Cnr2 | mCB2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38220.43
Organism:
MOUSE
Description:
P47936
Residue:
347
Sequence:
MEGCRETEVTNGSNGGLEFNPMKEYMILSSGQQIAVAVLCTLMGLLSALENMAVLYIILSSRRLRRKPSYLFISSLAGADFLASVIFACNFVIFHVFHGVDSNAIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALCVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHRHVATLAEHQDRQVPGIARMRLDVRLAKTLGLVLAVLLICWFPALALMGHSLVTTLSDQVKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLIGWKKYLQGLGPEGKEEGPRSSVTETEADVKTT
  
Inhibitor
Name:
BDBM50258739
Synonyms:
CHEMBL4064299
Type:
Small organic molecule
Emp. Form.:
C20H15ClN2O3
Mol. Mass.:
366.798
SMILES:
Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc3OCOc3c2)cc1
Structure:
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