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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50259923
Substrate
n/a
Meas. Tech.
ChEBML_1691998
EC50
62±n/a nM
Citation
 Hill, MD; Fang, H; Digavalli, SV; Healy, FL; Gallagher, L; Post-Munson, D; Chen, P; Natale, J; Benitex, Y; Morgan, D; Lodge, N; Bristow, L; Macor, JE; Olson, RE Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists. Bioorg Med Chem Lett 27:578-581 (2017) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50259923
Synonyms:
CHEMBL4078355
Type:
Small organic molecule
Emp. Form.:
C15H18ClN7
Mol. Mass.:
331.803
SMILES:
Clc1ccc2c(NC3=NCC4(CN5CCC4CC5)N3)ncnn12 |t:7,THB:18:10:13.14:16.17,(37.59,-16.14,;36.12,-15.66,;34.88,-16.57,;33.64,-15.66,;34.11,-14.2,;33.35,-12.86,;31.81,-12.86,;31.04,-14.19,;31.66,-15.6,;30.51,-16.63,;29.18,-15.86,;28.97,-17.24,;27.05,-16.44,;25.65,-17.37,;26,-15.97,;27.7,-15.21,;27.63,-13.57,;27.05,-14.97,;29.5,-14.35,;34.11,-11.52,;35.66,-11.53,;36.43,-12.87,;35.65,-14.2,)|
Structure:
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