Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM50260351
Substrate
n/a
Meas. Tech.
ChEBML_1693534
IC50
1.000000±n/a nM
Citation
 Miltz, W; Velcicky, J; Dawson, J; Littlewood-Evans, A; Ludwig, MG; Seuwen, K; Feifel, R; Oberhauser, B; Meyer, A; Gabriel, D; Nash, M; Loetscher, P Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis. Bioorg Med Chem 25:4512-4525 (2017) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50260351
Synonyms:
CHEMBL4086667
Type:
Small organic molecule
Emp. Form.:
C30H42N6
Mol. Mass.:
486.6947
SMILES:
CC(C)(C)CN(Cc1ccc(\C=C\CN2CCC(CC2)N2CCCCC2)cc1)c1ccnc(n1)C#N
Structure:
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