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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50262317
Substrate
n/a
Meas. Tech.
ChEMBL_1696732 (CHEMBL4047622)
IC50
20±n/a nM
Citation
 Bhide, RS; Keon, A; Weigelt, C; Sack, JS; Schmidt, RJ; Lin, S; Xiao, HY; Spergel, SH; Kempson, J; Pitts, WJ; Carman, J; Poss, MA Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors. Bioorg Med Chem Lett 27:4908-4913 (2017) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50262317
Synonyms:
CHEMBL4069401
Type:
Small organic molecule
Emp. Form.:
C22H21N5O3S
Mol. Mass.:
435.499
SMILES:
NC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H]([C@H](O)CO)c1ccccc1 |r|
Structure:
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