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Target
Atrial natriuretic peptide receptor 1
Ligand
BDBM50262459
Substrate
n/a
Meas. Tech.
ChEBML_1696823
EC50
3400±n/a nM
Citation
 Iwaki, T; Nakamura, Y; Tanaka, T; Ogawa, Y; Iwamoto, O; Okamura, Y; Kawase, Y; Furuya, M; Oyama, Y; Nagayama, T Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists. Bioorg Med Chem Lett 27:4904-4907 (2017) [PubMed]  Article 
Target
Name:
Atrial natriuretic peptide receptor 1
Synonyms:
ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1
Type:
PROTEIN
Mol. Mass.:
118919.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_700223
Residue:
1061
Sequence:
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
  
Inhibitor
Name:
BDBM50262459
Synonyms:
CHEMBL4093843
Type:
Small organic molecule
Emp. Form.:
C30H40N6O
Mol. Mass.:
500.6782
SMILES:
CC(C)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)C2CCCN(C)C2)c2ccc(cc2n1)-c1ccccc1 |r,wU:11.14,wD:8.7,(18.57,-18.93,;17.24,-19.71,;17.25,-21.25,;15.91,-18.94,;14.58,-19.72,;14.58,-21.27,;13.24,-22.04,;13.24,-23.58,;14.58,-24.35,;14.57,-25.88,;15.9,-26.65,;17.23,-25.89,;17.24,-24.35,;15.9,-23.57,;18.56,-26.67,;19.9,-25.9,;19.91,-24.36,;21.23,-26.68,;22.56,-25.91,;23.9,-26.69,;23.89,-28.23,;22.54,-28.99,;22.53,-30.53,;21.22,-28.22,;11.91,-21.27,;10.58,-22.03,;9.25,-21.27,;9.25,-19.72,;10.58,-18.96,;11.91,-19.73,;13.24,-18.95,;7.92,-18.95,;7.92,-17.41,;6.59,-16.64,;5.25,-17.41,;5.26,-18.96,;6.59,-19.72,)|
Structure:
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