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Target
Proteasome subunit beta type-5
Ligand
BDBM50267349
Substrate
n/a
Meas. Tech.
ChEMBL_1702752 (CHEMBL4053985)
IC50
>1000±n/a nM
Citation
 Jorda, R; Du?ek, J; ?ezní?ková, E; Pauk, K; Magar, PP; Imramovský, A; Kry?tof, V Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine. Eur J Med Chem 135:142-158 (2017) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50267349
Synonyms:
CHEMBL4105518
Type:
Small organic molecule
Emp. Form.:
C23H20ClNO3
Mol. Mass.:
393.863
SMILES:
Clc1ccc(OCc2ccccc2)c(c1)C(=O)N[C@@H](Cc1ccccc1)C=O |r|
Structure:
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