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Target
Somatostatin receptor type 5
Ligand
BDBM50268214
Substrate
n/a
Meas. Tech.
ChEMBL_1704594 (CHEMBL4055827)
IC50
2.6±n/a nM
Citation
 Yamasaki, T; Hirose, H; Yamashita, T; Takakura, N; Morimoto, S; Nakahata, T; Kina, A; Nakano, Y; Okano Tamura, Y; Sugama, J; Odani, T; Shimizu, Y; Iwasaki, S; Watanabe, M; Maekawa, T; Kasai, S Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition. Bioorg Med Chem 25:4153-4162 (2017) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 5
Synonyms:
SOMATOSTATIN SST5 | SS-5-R | SS5-R | SS5R | SSR5_HUMAN | SSTR5 | Somatostatin receptor type 5 (SSTR5)
Type:
Enzyme
Mol. Mass.:
39218.02
Organism:
Homo sapiens (Human)
Description:
P35346
Residue:
364
Sequence:
MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
  
Inhibitor
Name:
BDBM50268214
Synonyms:
CHEMBL4070852
Type:
Small organic molecule
Emp. Form.:
C30H36FN3O4
Mol. Mass.:
521.6229
SMILES:
CCOc1cc(-c2ccc(F)cc2)c(cc1CN1CC2(C1)CC(=NO2)N1CCC(C)(CC1)C(O)=O)C1CC1 |c:25|
Structure:
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