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Target
dCTP pyrophosphatase 1
Ligand
BDBM50241049
Substrate
n/a
Meas. Tech.
ChEMBL_1705780 (CHEMBL4057013)
IC50
30900±n/a nM
Citation
 Llona-Minguez, S; Häggblad, M; Martens, U; Throup, A; Loseva, O; Jemth, AS; Lundgren, B; Scobie, M; Helleday, T Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines. Bioorg Med Chem Lett 27:3897-3904 (2017) [PubMed]  Article 
Target
Name:
dCTP pyrophosphatase 1
Synonyms:
DCTP1_HUMAN | DCTPP1 | Deoxycytidine-triphosphatase 1 | XTP3TPA | dCTP pyrophosphatase 1 | dCTP pyrophosphatase 1 (DCTPP1)
Type:
Protein
Mol. Mass.:
18673.58
Organism:
Homo sapiens (Human)
Description:
Q9H773
Residue:
170
Sequence:
MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
  
Inhibitor
Name:
BDBM50241049
Synonyms:
CHEMBL463763 | Triptolide, 1 | triptolide
Type:
Small organic molecule
Emp. Form.:
C20H24O6
Mol. Mass.:
360.401
SMILES:
CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3C[C@H]3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O |r,c:17|
Structure:
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