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Target
Choline kinase alpha
Ligand
BDBM50275672
Substrate
n/a
Meas. Tech.
ChEMBL_1714831 (CHEMBL4124880)
IC50
920±n/a nM
Citation
 Schiafino-Ortega, S; Baglioni, E; Pérez-Moreno, G; Marco, PR; Marco, C; González-Pacanowska, D; Ruiz-Pérez, LM; Carrasco-Jiménez, MP; López-Cara, LC 1,2-Diphenoxiethane salts as potent antiplasmodial agents. Bioorg Med Chem Lett 28:2485-2489 (2018) [PubMed]  Article 
Target
Name:
Choline kinase alpha
Synonyms:
CHK | CHKA | CHKA_HUMAN | CKI | Choline kinase alpha
Type:
PROTEIN
Mol. Mass.:
52248.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1290064
Residue:
457
Sequence:
MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
  
Inhibitor
Name:
BDBM50275672
Synonyms:
CHEMBL4128522
Type:
Small organic molecule
Emp. Form.:
C42H42Br2Cl2N4O2
Mol. Mass.:
865.522
SMILES:
[Br-].[Br-].Clc1ccc2c(cc[n+](Cc3ccc(OCCOc4ccc(C[n+]5ccc(N6CCCC6)c6ccc(Cl)cc56)cc4)cc3)c2c1)N1CCCC1
Structure:
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