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Target
Dihydrofolate reductase
Ligand
BDBM50008287
Substrate
n/a
Meas. Tech.
ChEBML_54604
Ki
0.007000±n/a nM
Citation
 DeGraw, JI; Christie, PH; Kisliuk, RL; Gaumont, Y; Sirotnak, FM Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid. J Med Chem 33:673-7 (1990) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MOUSE | Dhfr
Type:
Enzyme
Mol. Mass.:
21608.82
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50008287
Synonyms:
2-{4-[2-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-yl)-1-methyl-ethyl]-benzoylamino}-pentanedioic acid | CHEMBL110251
Type:
Small organic molecule
Emp. Form.:
C22H24N6O5
Mol. Mass.:
452.4632
SMILES:
CC(Cc1cnc2nc(N)nc(N)c2c1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O
Structure:
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