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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1/2
Ligand
BDBM50406362
Substrate
n/a
Meas. Tech.
ChEMBL_204728 (CHEMBL805029)
Ki
140±n/a nM
Citation
 Holt, DA; Levy, MA; Oh, HJ; Erb, JM; Heaslip, JI; Brandt, M; Lan-Hargest, HY; Metcalf, BW Inhibition of steroid 5 alpha-reductase by unsaturated 3-carboxysteroids. J Med Chem 33:943-50 (1990) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1/2
Synonyms:
Steroid 5-alpha-reductase
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 204723
Components:
This complex has 2 components.
Component 1
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
S5A1_RAT | Srd5a1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
PROTEIN
Mol. Mass.:
29788.29
Organism:
Rattus norvegicus
Description:
ChEMBL_1441437
Residue:
259
Sequence:
MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQELPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLAFLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWYHEKFEDYPKSRKILIPFVL
  
Component 2
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
S5A2_RAT | Srd5a2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2
Type:
PROTEIN
Mol. Mass.:
28784.15
Organism:
Rattus norvegicus
Description:
ChEMBL_205054
Residue:
254
Sequence:
MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPSFVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCIGNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRIPRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFKDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50406362
Synonyms:
CHEMBL170473
Type:
Small organic molecule
Emp. Form.:
C21H27NO2
Mol. Mass.:
325.4446
SMILES:
C[C@]12CCC3C(CC=C4C=C(CC[C@]34C)C(O)=O)C1CC[C@@H]2C#N |c:9,t:7|
Structure:
Search PDB for entries with ligand similarity: