Reaction Details Report a problem with these data
Target
Cellular tumor antigen p53
Ligand
BDBM118299
Substrate
n/a
Meas. Tech.
ChEMBL_1719235 (CHEMBL4134235)
IC50
>3000±n/a nM
Citation
Hoegenauer, K; Soldermann, N; Zécri, F; Strang, RS; Graveleau, N; Wolf, RM; Cooke, NG; Smith, AB; Hollingworth, GJ; Blanz, J; Gutmann, S; Rummel, G; Littlewood-Evans, A; Burkhart, C Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. ACS Med Chem Lett 8:975-980 (2017) [PubMed] Article
More Info.:
Target
Name:
Cellular tumor antigen p53
Synonyms:
Antigen NY-CO-13 | CREB-binding protein/p53 | GST-p53 | His6-p53 | P53 | P53_HUMAN | Phosphoprotein p53 | TP53 | Tumor Suppressor p53
Type:
fusion protein
Mol. Mass.:
43654.73
Organism:
Homo sapiens (Human)
Description:
The full-length His6-wt-p53 expressed in E. coli was used in assays.
Residue:
393
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD