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Target
Translocator protein
Ligand
BDBM50279019
Substrate
n/a
Meas. Tech.
ChEMBL_1720334 (CHEMBL4135334)
IC50
25±n/a nM
Citation
 Kim, T; Son, WS; Morshed, MN; Londhe, AM; Jung, SY; Park, JH; Park, WK; Lim, SM; Park, KD; Cho, SJ; Jeong, KS; Lee, J; Pae, AN Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against A?-induced neurotoxicity. Eur J Med Chem 141:240-256 (2017) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50279019
Synonyms:
CHEMBL1315992
Type:
Small organic molecule
Emp. Form.:
C19H18N4OS2
Mol. Mass.:
382.502
SMILES:
CCc1nnc(SCC(=O)N(C)c2ccccc2)c2cc3sccc3n12
Structure:
Search PDB for entries with ligand similarity: