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Target
Cytochrome P450 2C8
Ligand
BDBM50286071
Substrate
n/a
Meas. Tech.
ChEMBL_1728915 (CHEMBL4144193)
IC50
>100000±n/a nM
Citation
 Ogoshi, Y; Matsui, T; Mitani, I; Yokota, M; Terashita, M; Motoda, D; Ueyama, K; Hotta, T; Ito, T; Hase, Y; Fukui, K; Deai, K; Yoshiuchi, H; Ito, S; Abe, H Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ACS Med Chem Lett 8:1320-1325 (2017) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C8
Synonyms:
CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase
Type:
Protein
Mol. Mass.:
55839.23
Organism:
Homo sapiens (Human)
Description:
P10632
Residue:
490
Sequence:
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
  
Inhibitor
Name:
BDBM50286071
Synonyms:
CHEMBL4166742
Type:
Small organic molecule
Emp. Form.:
C17H17ClN4O4
Mol. Mass.:
376.794
SMILES:
Cl.OC(=O)CNC(=O)c1c(O)cc(CCc2ccccc2)n2ncnc12
Structure:
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