Reaction Details Report a problem with these data
Target
rRNA adenine N-6-methyltransferase
Ligand
BDBM50291839
Substrate
n/a
Meas. Tech.
ChEMBL_1731832 (CHEMBL4147368)
IC50
250000±n/a nM
Citation
 Foik, IP; Tuszynska, I; Feder, M; Purta, E; Stefaniak, F; Bujnicki, JM Novel inhibitors of the rRNA ErmC' methyltransferase to block resistance to macrolides, lincosamides, streptogramine B antibiotics. Eur J Med Chem 146:60-67 (2018) [PubMed]  Article 
Target
Name:
rRNA adenine N-6-methyltransferase
Synonyms:
2.1.1.184 | ERMA_STAAN | Erythromycin resistance protein | Macrolide-lincosamide-streptogramin B resistance protein | ermA1 | ermA2 | ermA3 | ermA4 | ermA5 | rRNA adenine N-6-methyltransferase
Type:
PROTEIN
Mol. Mass.:
28433.06
Organism:
Staphylococcus aureus (strain N315)
Description:
ChEMBL_117813
Residue:
243
Sequence:
MNQKNPKDTQNFITSKKHVKEILNHTNISKQDNVIEIGSGKGHFTKELVKMSRSVTAIEIDGGLCQVTKEAVNPSENIKVIQTDILKFSFPKHINYKIYGNIPYNISTDIVKRITFESQAKYSYLIVEKGFAKRLQNLQRALGLLLMVEMDIKMLKKVPPLYFHPKPSVDSVLIVLERHQPLISKKDYKKYRSFVYKWVNREYRVLFTKNQFRQALKHANVTNINKLSKEQFLSIFNSYKLFH
  
Inhibitor
Name:
BDBM50291839
Synonyms:
CHEMBL4176350
Type:
Small organic molecule
Emp. Form.:
C16H11ClO5S2
Mol. Mass.:
382.839
SMILES:
COC(=O)c1sc2ccccc2c1OS(=O)(=O)c1ccc(Cl)cc1
Structure:
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