Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50017399
Substrate
n/a
Meas. Tech.
ChEBML_146550
Ki
214±n/a nM
Citation
 Bagley, JR; Wynn, RL; Rudo, FG; Doorley, BM; Spencer, HK; Spaulding, T New 4-(heteroanilido)piperidines, structurally related to the pure opioid agonist fentanyl, with agonist and/or antagonist properties. J Med Chem 32:663-71 (1989) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50017399
Synonyms:
CHEMBL161280 | N-(6-Chloro-pyrimidin-4-yl)-2-methoxy-N-(1-phenethyl-piperidin-4-yl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C20H25ClN4O2
Mol. Mass.:
388.891
SMILES:
COCC(=O)N(C1CCN(CCc2ccccc2)CC1)c1cc(Cl)ncn1
Structure:
Search PDB for entries with ligand similarity: