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Target
Pancreatic triacylglycerol lipase
Ligand
BDBM50367135
Substrate
n/a
Meas. Tech.
ChEMBL_1735716 (CHEMBL4151252)
IC50
6220±n/a nM
Citation
 Jalaja, R; Leela, SG; Valmiki, PK; Salfeena, CTF; Ashitha, KT; Krishna Rao, VRD; Nair, MS; Gopalan, RK; Somappa, SB Discovery of Natural Product Derived Labdane Appended Triazoles as Potent Pancreatic Lipase Inhibitors. ACS Med Chem Lett 9:662-666 (2018) [PubMed]  Article 
Target
Name:
Pancreatic triacylglycerol lipase
Synonyms:
LIPP_PIG | PL | PNLIP | PTL | Pancreatic lipase | Pancreatic triacylglycerol lipase
Type:
Enzyme
Mol. Mass.:
50080.69
Organism:
Sus scrofa (Pig)
Description:
P00591
Residue:
450
Sequence:
SEVCFPRLGCFSDDAPWAGIVQRPLKILPWSPKDVDTRFLLYTNQNQNNYQELVADPSTITNSNFRMDRKTRFIIHGFIDKGEEDWLSNICKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEVLKSSLGYSPSNVHVIGHSLGSHAAGEAGRRTNGTIERITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGKQMPGCQKNILSQIVDIDGIWEGTRDFVACNHLRSYKYYADSILNPDGFAGFPCDSYNVFTANKCFPCPSEGCPQMGHYADRFPGKTNGVSQVFYLNTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNEGNSRQYEIYKGTLQPDNTHSDEFDSDVEVGDLQKVKFIWYNNNVINPTLPRVGASKITVERNDGKVYDFCSQETVREEVLLTLNPC
  
Inhibitor
Name:
BDBM50367135
Synonyms:
CHEMBL4160094
Type:
Small organic molecule
Emp. Form.:
C31H39N3O4
Mol. Mass.:
517.6591
SMILES:
[H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(CC(=O)c4ccccc4)nn3)C=O)[C@@]1(C)CCCC2(C)C |r|
Structure:
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