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Target
Cellular tumor antigen p53
Ligand
BDBM50404078
Substrate
n/a
Meas. Tech.
ChEMBL_1738290 (CHEMBL4154040)
Kd
20000±n/a nM
Citation
 Baud, MGJ; Bauer, MR; Verduci, L; Dingler, FA; Patel, KJ; Horil Roy, D; Joerger, AC; Fersht, AR Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem 152:101-114 (2018) [PubMed]  Article 
Target
Name:
Cellular tumor antigen p53
Synonyms:
Antigen NY-CO-13 | CREB-binding protein/p53 | GST-p53 | His6-p53 | P53 | P53_HUMAN | Phosphoprotein p53 | TP53 | Tumor Suppressor p53
Type:
fusion protein
Mol. Mass.:
43654.73
Organism:
Homo sapiens (Human)
Description:
The full-length His6-wt-p53 expressed in E. coli was used in assays.
Residue:
393
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
  
Inhibitor
Name:
BDBM50404078
Synonyms:
CHEMBL4172014
Type:
Small organic molecule
Emp. Form.:
C11H9I2NO2
Mol. Mass.:
441.0036
SMILES:
OCc1cc(I)c(c(I)c1O)-n1cccc1
Structure:
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