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Target
Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands
Ligand
BDBM50151363
Substrate
n/a
Meas. Tech.
ChEMBL_1743513 (CHEMBL4178023)
IC50
>10000±n/a nM
Citation
 Osman, KT; Ye, J; Shi, Z; Toker, C; Lovato, D; Jumani, RS; Zuercher, W; Huston, CD; Edwards, AM; Lautens, M; Santhakumar, V; Hui, R Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor. Bioorg Med Chem 25:1672-1680 (2017) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands
Synonyms:
Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands
Type:
PROTEIN
Mol. Mass.:
93057.92
Organism:
Cryptosporidium parvum (strain Iowa II)
Description:
ChEMBL_118090
Residue:
824
Sequence:
IRQGHIVNNNKMEKNRGKTRTPVSRQGSKPASGLRSAQNLHSSERKGVSIGFDKLRDGVTSSIENTPVRQTSSRKVDQNSSCNRKCQSTESYRTRTKLESSERDKAMCFSPAFKLKFSHNAFVSLGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSDKIYKMSPIAGIEAHESHSSRRNIFGATEHSPVQISMLKSLRRYYVSPLLKKIALTVIARYCPDKWIENLRNVFYKLDTRQIGKINLYDLRVATQQLVAQQKLKVPQHHIDLLLDAVDSDGNGEIDYIEFVAAVISPKLSCRKDVLTMAFKMLDQDEDGLISTRDIKKLVSSEKIRLSSATVLEAEEDSILEDLNVEVTKVIGKGNENVTGISFQAFEKLLNTSYDKVCRCYHGPREGETKGRLPVCGEDSMDTWYDDLLSCNTENENLTQLFAGSEPRRLQKNSLYVCRRTGFRDLLALSQGAGQKDKFQVEMNRKRSLGNHQEREAYSTKGAKDEGQSSGEMNREYGLGIVGFIGNGLGVRMGGNTKNPSKVLLCDS
  
Inhibitor
Name:
BDBM50151363
Synonyms:
4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiazol-2-ylamine | 4-(3-chlorophenyl)-5-(1,5-naphthyridin-2-yl)thiazol-2-amine | CHEMBL365663
Type:
Small organic molecule
Emp. Form.:
C17H11ClN4S
Mol. Mass.:
338.814
SMILES:
Nc1nc(c(s1)-c1ccc2ncccc2n1)-c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: