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Target
Sensor protein kinase WalK
Ligand
BDBM50453886
Substrate
n/a
Meas. Tech.
ChEMBL_1751469 (CHEMBL4186229)
IC50
24000±n/a nM
Citation
 Vo, CD; Shebert, HL; Zikovich, S; Dryer, RA; Huang, TP; Moran, LJ; Cho, J; Wassarman, DR; Falahee, BE; Young, PD; Gu, GH; Heinl, JF; Hammond, JW; Jackvony, TN; Frederick, TE; Blair, JA Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. Bioorg Med Chem Lett 27:5235-5244 (2017) [PubMed]  Article 
Target
Name:
Sensor protein kinase WalK
Synonyms:
2.7.13.3 | Sensor protein kinase WalK | WALK_STAEQ | walK | yycG | yycG
Type:
PROTEIN
Mol. Mass.:
69934.00
Organism:
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Description:
ChEMBL_118093
Residue:
610
Sequence:
MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNSLEKELLDNFKKNITQYAKQLDVNIEKVYKDKDKGSVNAQKDIQDLLNEYANRQEIGEIRFIDKDQIIMATTKQSNRGLINQKVNDGSVQKALSLGQTNDHMVLKDYGSGKERVWVYNIPVKVDKQTIGDIYIESKINDVYNQLNNINQIFIVGTAISLFITVILGFFIARTITKPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGILATDRRGRVRIANDMALKMLGLAKEDVIGYYMLGVLNLENEFSLEEIQENSDSFLLDINEEEGIIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALEEGAWQDKELAPSFLSVTREETERMIRLVNDLLQLSKMDNESDQITKEIIDFNMFINKIINRHEMAAKDTTFVREIPQQTIFAEIDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKQNALYNRMTIRIKDNGIGIPINKVDKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEIIEDGDWDE
  
Inhibitor
Name:
BDBM50453886
Synonyms:
CHEMBL4215525
Type:
Small organic molecule
Emp. Form.:
C27H17FN2O3S2
Mol. Mass.:
500.564
SMILES:
OC(=O)c1ccc(cc1)-c1ccc(\C=C2/S\C(=N/c3ccccc3)N(C2=O)c2ccc(F)cc2)s1
Structure:
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