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Target
Tubulin alpha-1A chain
Ligand
BDBM50020480
Substrate
n/a
Meas. Tech.
ChEBML_211863
IC50
5200±n/a nM
Citation
 Kruse, LI; Ladd, DL; Harrsch, PB; McCabe, FL; Mong, SM; Faucette, L; Johnson, R Synthesis, tubulin binding, antineoplastic evaluation, and structure-activity relationship of oncodazole analogues. J Med Chem 32:409-17 (1989) [PubMed]  Article 
Target
Name:
Tubulin alpha-1A chain
Synonyms:
TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain
Type:
Protein
Mol. Mass.:
50049.25
Organism:
Sus scrofa (Pig)
Description:
P02550
Residue:
451
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
  
Inhibitor
Name:
BDBM50020480
Synonyms:
CHEMBL422615 | [5-(2-Methoxycarbonylamino-1H-benzoimidazole-5-carbonyl)-thiophen-3-yl]-acetic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C23H19N3O5S
Mol. Mass.:
449.479
SMILES:
COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c1cc(CC(=O)OCc2ccccc2)cs1
Structure:
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