Reaction Details Report a problem with these data
Target
Menin
Ligand
BDBM152211
Substrate
n/a
Meas. Tech.
ChEMBL_1752090 (CHEMBL4186850)
IC50
1900±n/a nM
Citation
 Wang, ZH; Li, DD; Chen, WL; You, QD; Guo, XK Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy. Bioorg Med Chem 26:356-365 (2018) [PubMed]  Article 
Target
Name:
Menin
Synonyms:
MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2
Type:
Protein
Mol. Mass.:
68022.55
Organism:
Homo sapiens (Human)
Description:
O00255
Residue:
610
Sequence:
MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL
  
Inhibitor
Name:
BDBM152211
Synonyms:
BDBM152229 | US8993552, 1
Type:
Small organic molecule
Emp. Form.:
C19H25N5S2
Mol. Mass.:
387.565
SMILES:
CC1(C)CN=C(S1)N1CCN(CC1)c1ncnc2sc3CCCCc3c12 |c:4|
Structure:
Search PDB for entries with ligand similarity: