Reaction Details Report a problem with these data
Target
TGF-beta receptor type-2
Ligand
BDBM406696
Substrate
n/a
Meas. Tech.
ChEMBL_1753652 (CHEMBL4188412)
IC50
77±n/a nM
Citation
Harikrishnan, LS; Warrier, J; Tebben, AJ; Tonukunuru, G; Madduri, SR; Baligar, V; Mannoori, R; Seshadri, B; Rahaman, H; Arunachalam, PN; Dikundwar, AG; Fink, BE; Fargnoli, J; Fereshteh, M; Fan, Y; Lippy, J; Ho, CP; Wautlet, B; Sheriff, S; Ruzanov, M; Borzilleri, RM Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGF?RI). Bioorg Med Chem 26:1026-1034 (2018) [PubMed] Article
More Info.:
Target
Name:
TGF-beta receptor type-2
Synonyms:
TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
64559.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586859
Residue:
567
Sequence:
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK