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Target
Meprin A subunit beta
Ligand
BDBM13080
Substrate
n/a
Meas. Tech.
ChEMBL_1754877 (CHEMBL4189637)
Ki
7400±n/a nM
Citation
 Ramsbeck, D; Hamann, A; Richter, G; Schlenzig, D; Geissler, S; Nykiel, V; Cynis, H; Schilling, S; Buchholz, M Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin ? Inhibitors. J Med Chem 61:4578-4592 (2018) [PubMed]  Article 
Target
Name:
Meprin A subunit beta
Synonyms:
3.4.24.63 | Endopeptidase-2 | MEP1B | MEP1B_HUMAN | Meprin A subunit beta | Meprin B | N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta | PABA peptide hydrolase | PPH beta
Type:
PROTEIN
Mol. Mass.:
79560.71
Organism:
Homo sapiens
Description:
ChEMBL_117484
Residue:
701
Sequence:
MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTPAPSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSSTVAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNQHAF
  
Inhibitor
Name:
BDBM13080
Synonyms:
CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenzene)(2-methylpropyl)sulfonamido]acetamide | US20230357139, Compound A | US20240050571, Compound NNGH
Type:
Small organic molecule
Emp. Form.:
C13H20N2O5S
Mol. Mass.:
316.373
SMILES:
COc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO
Structure:
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