Reaction Details Report a problem with these data
Target
Thymidylate synthase
Ligand
BDBM50021750
Substrate
n/a
Meas. Tech.
ChEBML_209970
Ki
1900±n/a nM
Citation
Al-Razzak, LA; Schwepler, D; Decedue, CJ; Balzarini, J; De Clercq, E; Mertes, MP 5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies. J Med Chem 30:409-19 (1987) [PubMed] Article
More Info.:
Target
Name:
Thymidylate synthase
Synonyms:
TS | TSase | TYSY_MOUSE | Tyms
Type:
PROTEIN
Mol. Mass.:
34957.15
Organism:
Mus musculus
Description:
ChEMBL_1340097
Residue:
307
Sequence:
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
Inhibitor
Name:
BDBM50021750
Synonyms:
CHEMBL3143104 | Phosphoric acid mono-{3-hydroxy-5-[5-(3-methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-2-ylmethyl} ester
Type:
Small organic molecule
Emp. Form.:
C20H19N2O10P
Mol. Mass.:
478.346
SMILES:
CC1=C(C(=O)c2ccccc2C1=O)c1cn([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)c(=O)[nH]c1=O |r,t:1|