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Target
Phosphatidylinositol 4-kinase beta
Ligand
BDBM50457862
Substrate
n/a
Meas. Tech.
ChEMBL_1760892 (CHEMBL4195900)
IC50
23±n/a nM
Citation
 Reuberson, J; Horsley, H; Franklin, RJ; Ford, D; Neuss, J; Brookings, D; Huang, Q; Vanderhoydonck, B; Gao, LJ; Jang, MY; Herdewijn, P; Ghawalkar, A; Fallah-Arani, F; Khan, AR; Henshall, J; Jairaj, M; Malcolm, S; Ward, E; Shuttleworth, L; Lin, Y; Li, S; Louat, T; Waer, M; Herman, J; Payne, A; Ceska, T; Doyle, C; Pitt, W; Calmiano, M; Augustin, M; Steinbacher, S; Lammens, A; Allen, R Discovery of a Potent, Orally Bioavailable PI4KIII? Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo. J Med Chem 61:6705-6723 (2018) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 4-kinase beta
Synonyms:
NPIK | PI4-kinase beta subunit | PI4K-beta | PI4K92 | PI4KB | PI4KB_HUMAN | PI4Kbeta | PIK4B | PIK4CB | Phosphatidylinositol 4-kinase beta | Phosphatidylinositol 4-kinase, PI4K | PtdIns 4-kinase beta
Type:
Protein
Mol. Mass.:
91373.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
816
Sequence:
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
  
Inhibitor
Name:
BDBM50457862
Synonyms:
CHEMBL4204100
Type:
Small organic molecule
Emp. Form.:
C18H21N7O2S
Mol. Mass.:
399.47
SMILES:
COc1ccc(NC(=O)N2CCN(C(C)C2)c2nc(N)nc3scnc23)cc1
Structure:
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