Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50020221
Substrate
n/a
Meas. Tech.
ChEMBL_1764020 (CHEMBL4199267)
Ki
466±n/a nM
Citation
 Modica, MN; Lacivita, E; Intagliata, S; Salerno, L; Romeo, G; Pittalą, V; Leopoldo, M Structure-Activity Relationships and Therapeutic Potentials of 5-HT J Med Chem 61:8475-8503 (2018) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50020221
Synonyms:
(-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol | 5-hydroxy-2-(dipropylamino)tetralin | 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol | 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol (DP-5-ADTN) | CHEMBL273273
Type:
Small organic molecule
Emp. Form.:
C16H25NO
Mol. Mass.:
247.3758
SMILES:
CCCN(CCC)C1CCc2c(O)cccc2C1
Structure:
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