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Target
Urotensin-2 receptor
Ligand
BDBM50459264
Substrate
n/a
Meas. Tech.
ChEMBL_1766050 (CHEMBL4201297)
EC50
1.3±n/a nM
Citation
 Billard, E; Hébert, TE; Chatenet, D Discovery of New Allosteric Modulators of the Urotensinergic System through Substitution of the Urotensin II-Related Peptide (URP) Phenylalanine Residue. J Med Chem 61:8707-8716 (2018) [PubMed]  Article 
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | G-protein coupled sensory epithelial neuropeptide-like receptor | Gpr14 | Senr | UR-II-R | UR2R_RAT | Urotensin-II | Uts2r
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42725.34
Organism:
RAT
Description:
Urotensin-II UTS2R RAT::P49684
Residue:
386
Sequence:
MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
  
Inhibitor
Name:
BDBM50459264
Synonyms:
CHEMBL4216988
Type:
Small organic molecule
Emp. Form.:
C57H68N10O10S2
Mol. Mass.:
1117.341
SMILES:
CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](C)N)C(=O)N[C@@H](Cc2ccc(cc2)C#Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O |r|
Structure:
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