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Target
Protein ENL
Ligand
BDBM50459744
Substrate
n/a
Meas. Tech.
ChEMBL_1767020 (CHEMBL4202267)
Ki
63±n/a nM
Citation
 Du, L; Grigsby, SM; Yao, A; Chang, Y; Johnson, G; Sun, H; Nikolovska-Coleska, Z Peptidomimetics for Targeting Protein-Protein Interactions between DOT1L and MLL Oncofusion Proteins AF9 and ENL. ACS Med Chem Lett 9:895-900 (2018) [PubMed]  Article 
Target
Name:
Protein ENL
Synonyms:
ENL | ENL_HUMAN | LTG19 | MLLT1 | Protein ENL | YEATS domain-containing protein 1 | YEATS1
Type:
PROTEIN
Mol. Mass.:
62068.50
Organism:
Homo sapiens
Description:
ChEMBL_118046
Residue:
559
Sequence:
MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSCLEAVAT
  
Inhibitor
Name:
BDBM50459744
Synonyms:
CHEMBL4204744
Type:
Small organic molecule
Emp. Form.:
C56H96N12O10S
Mol. Mass.:
1129.501
SMILES:
[H][C@@]12CS[C@@H](CCCCC(=O)NCCCCCC(=O)N[C@@H](CC(C)C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC3CCCC3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)N(C)C)[C@]1([H])NC(=O)N2 |r|
Structure:
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