Reaction Details Report a problem with these data
Target
G-protein coupled estrogen receptor 1
Ligand
BDBM50459751
Substrate
n/a
Meas. Tech.
ChEMBL_1767035 (CHEMBL4202282)
EC50
1620±n/a nM
Citation
 O'Dea, A; Sondergard, C; Sweeney, P; Arnatt, CK A Series of Indole-Thiazole Derivatives Act as GPER Agonists and Inhibit Breast Cancer Cell Growth. ACS Med Chem Lett 9:901-906 (2018) [PubMed]  Article 
Target
Name:
G-protein coupled estrogen receptor 1
Synonyms:
CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30
Type:
PROTEIN
Mol. Mass.:
42259.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_982507
Residue:
375
Sequence:
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
  
Inhibitor
Name:
BDBM50459751
Synonyms:
CHEMBL4212956
Type:
Small organic molecule
Emp. Form.:
C19H12ClF2N3OS
Mol. Mass.:
403.833
SMILES:
Fc1ccc(Cc2cnc(NC(=O)c3[nH]c4ccccc4c3Cl)s2)c(F)c1
Structure:
Search PDB for entries with ligand similarity: