Reaction Details Report a problem with these data
Target
Pro-cathepsin H
Ligand
BDBM50460502
Substrate
n/a
Meas. Tech.
ChEMBL_1769582 (CHEMBL4221694)
Ki
329000±n/a nM
Citation
 Sosi?, I; Mitrovi?, A; ?uri?, H; Knez, D; Brodnik ?ugelj, H; ?tefane, B; Kos, J; Gobec, S Cathepsin B inhibitors: Further exploration of the nitroxoline core. Bioorg Med Chem Lett 28:1239-1247 (2018) [PubMed]  Article 
Target
Name:
Pro-cathepsin H
Synonyms:
CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain
Type:
PROTEIN
Mol. Mass.:
37402.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459870
Residue:
335
Sequence:
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
  
Inhibitor
Name:
BDBM50460502
Synonyms:
CHEMBL4228576
Type:
Small organic molecule
Emp. Form.:
C14H10N4O4
Mol. Mass.:
298.2536
SMILES:
Oc1c(cc([N+]([O-])=O)c2cccnc12)C(=O)NC1(CC1)C#N
Structure:
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