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Target
Dopamine beta-hydroxylase
Ligand
BDBM50023370
Substrate
n/a
Meas. Tech.
ChEMBL_50738 (CHEMBL660770)
Ki
35000±n/a nM
Citation
 Kruse, LI; Kaiser, C; DeWolf, WE; Chambers, PA; Goodhart, PJ; Ezekiel, M; Ohlstein, EH Beta-substituted phenethylamines as high-affinity mechanism-based inhibitors of dopamine beta-hydroxylase. J Med Chem 31:704-6 (1988) [PubMed]  Article 
Target
Name:
Dopamine beta-hydroxylase
Synonyms:
DBH | DOPO_BOVIN
Type:
PROTEIN
Mol. Mass.:
68136.39
Organism:
Bos taurus
Description:
ChEMBL_50738
Residue:
610
Sequence:
MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISYAQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDSQQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSGLHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIVMYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMELGLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARDGRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSFNREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGPTVLNISGGKG
  
Inhibitor
Name:
BDBM50023370
Synonyms:
2-Thiophen-2-yl-allylamine | CHEMBL110604
Type:
Small organic molecule
Emp. Form.:
C7H9NS
Mol. Mass.:
139.218
SMILES:
NCC(=C)c1cccs1
Structure:
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