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Target
NEDD8-conjugating enzyme Ubc12
Ligand
BDBM50245225
Substrate
n/a
Meas. Tech.
ChEMBL_1770455 (CHEMBL4222567)
Kd
1000±n/a nM
Citation
 Hammill, JT; Scott, DC; Min, J; Connelly, MC; Holbrook, G; Zhu, F; Matheny, A; Yang, L; Singh, B; Schulman, BA; Guy, RK Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem 61:2680-2693 (2018) [PubMed]  Article 
Target
Name:
NEDD8-conjugating enzyme Ubc12
Synonyms:
2.3.2.- | NEDD8 carrier protein | NEDD8-conjugating enzyme Ubc12 | UBC12 | UBC12_HUMAN | UBE2M | Ubiquitin-conjugating enzyme E2 M
Type:
PROTEIN
Mol. Mass.:
20901.74
Organism:
Homo sapiens
Description:
ChEMBL_118032
Residue:
183
Sequence:
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNFKLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK
  
Inhibitor
Name:
BDBM50245225
Synonyms:
CHEMBL4099097 | US11116757, No. A15
Type:
Small organic molecule
Emp. Form.:
C25H32F3N3O
Mol. Mass.:
447.5363
SMILES:
CCCC(C)N1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
Structure:
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