Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50023538
Substrate
n/a
Meas. Tech.
ChEBML_63669
IC50
1900±n/a nM
Citation
 Miyano, M; Deason, JR; Nakao, A; Stealey, MA; Villamil, CI; Sohn, DD; Mueller, RA (Acyloxy)benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase. J Med Chem 31:1052-61 (1988) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50023538
Synonyms:
Biphenyl-4-carboxylic acid 5-(2,2-dimethyl-propionyloxy)-4-oxo-4H-pyran-2-ylmethyl ester | CHEMBL10202
Type:
Small organic molecule
Emp. Form.:
C24H22O6
Mol. Mass.:
406.4279
SMILES:
CC(C)(C)C(=O)Oc1coc(COC(=O)c2ccc(cc2)-c2ccccc2)cc1=O
Structure:
Search PDB for entries with ligand similarity: