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Target
Proteasome subunit beta type-5
Ligand
BDBM50462603
Substrate
n/a
Meas. Tech.
ChEMBL_1776079 (CHEMBL4233071)
IC50
6.7±n/a nM
Citation
 Lei, M; Feng, H; Bai, E; Zhou, H; Wang, J; Shi, J; Wang, X; Hu, S; Liu, Z; Zhu, Y Design, synthesis, in vitro and in vivo evaluation, and structure-activity relationship (SAR) discussion of novel dipeptidyl boronic acid proteasome inhibitors as orally available anti-cancer agents for the treatment of multiple myeloma and mechanism studies. Bioorg Med Chem 26:3975-3981 (2018) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50462603
Synonyms:
CHEMBL4248209 | US11542283, Compound V-8A
Type:
Small organic molecule
Emp. Form.:
C20H30BCl2N3O5
Mol. Mass.:
474.186
SMILES:
COC[C@H](NC(=O)c1cc(Cl)ccc1Cl)C(=O)N[C@@H](CC(C)C)B1OCCNCCO1 |r|
Structure:
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