Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50462798
Substrate
n/a
Meas. Tech.
ChEMBL_1776530 (CHEMBL4233522)
Ki
5700±n/a nM
Citation
 Khanfar, MA; Reiner, D; Hagenow, S; Stark, H Design, synthesis, and biological evaluation of novel oxadiazole- and thiazole-based histamine H Bioorg Med Chem 26:4034-4046 (2018) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50462798
Synonyms:
CHEMBL4243827
Type:
Small organic molecule
Emp. Form.:
C13H17ClN4O
Mol. Mass.:
280.753
SMILES:
CN(C)CCCc1nnc(Nc2ccc(Cl)cc2)o1
Structure:
Search PDB for entries with ligand similarity: