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Target
2-Hydroxyacid oxidase 1
Ligand
BDBM50463047
Substrate
n/a
Meas. Tech.
ChEMBL_1777440 (CHEMBL4234432)
Ki
20300±n/a nM
Citation
 Moya-Garzón, MD; Martín Higueras, C; Peñalver, P; Romera, M; Fernandes, MX; Franco-Montalbán, F; Gómez-Vidal, JA; Salido, E; Díaz-Gavilán, M Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1. J Med Chem 61:7144-7167 (2018) [PubMed]  Article 
Target
Name:
2-Hydroxyacid oxidase 1
Synonyms:
1.1.3.15 | GOX | Glycolate oxidase | Gox1 | HAOX1 | HAOX1_MOUSE | Hao-1 | Hao1 | Hydroxyacid oxidase 1
Type:
PROTEIN
Mol. Mass.:
41003.92
Organism:
Mus musculus
Description:
ChEMBL_118230
Residue:
370
Sequence:
MLPRLVCISDYEQHVRSVLQKSVYDYYRSGANDQETLADNIQAFSRWKLYPRMLRNVADIDLSTSVLGQRVSMPICVGATAMQCMAHVDGELATVRACQTMGTGMMLSSWATSSIEEVAEAGPEALRWMQLYIYKDREISRQIVKRAEKQGYKAIFVTVDTPYLGNRIDDVRNRFKLPPQLRMKNFETNDLAFSPKGNFGDNSGLAEYVAQAIDPSLSWDDITWLRRLTSLPIVVKGILRGDDAKEAVKHGVDGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
  
Inhibitor
Name:
BDBM50463047
Synonyms:
CHEMBL1794748
Type:
Small organic molecule
Emp. Form.:
C9H5ClN2O2S2
Mol. Mass.:
272.731
SMILES:
OC(=O)c1nnsc1Sc1ccc(Cl)cc1
Structure:
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