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Target
Transient receptor potential cation channel subfamily V member 2
Ligand
BDBM50463979
Substrate
n/a
Meas. Tech.
ChEMBL_1779721 (CHEMBL4236713)
IC50
1900±n/a nM
Citation
 Schiano Moriello, A; López Chinarro, S; Novo Fernández, O; Eras, J; Amodeo, P; Canela-Garayoa, R; Vitale, RM; Di Marzo, V; De Petrocellis, L Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists. J Med Chem 61:8255-8281 (2018) [PubMed]  Article 
Target
Name:
Transient receptor potential cation channel subfamily V member 2
Synonyms:
Sac2b | TRPV2_RAT | Transient receptor potential cation channel subfamily V member 2 | Trpv2 | Vanilloid receptor | Vrl1
Type:
PROTEIN
Mol. Mass.:
86707.60
Organism:
Rattus norvegicus
Description:
ChEMBL_768011
Residue:
761
Sequence:
MTSASSPPAFRLETSDGDEEGNAEVNKGKQEPPPMESPFQREDRNSSPQIKVNLNFIKRPPKNTSAPSQQEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACYLVYMFIFTVVAYHQPSLDQPAIPSSKATFGESMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDNNSTVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGRLLKVGTRGDGTPDERWCFRVEEVNWAAWEKTLPTLSEDPSGPGITGNKKNPTSKPGKNSASEEDHLPLQVLQSP
  
Inhibitor
Name:
BDBM50463979
Synonyms:
CHEMBL4250167
Type:
Small organic molecule
Emp. Form.:
C31H51F3N2O5S
Mol. Mass.:
620.807
SMILES:
OC(=O)C(F)(F)F.CCCCCCCC\C=C/CCCCCCCCSC[C@H](N)C(=O)NCc1ccc(O)c(OC)c1 |r|
Structure:
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