Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50024649
Substrate
n/a
Meas. Tech.
ChEBML_201787
Ki
120000±n/a nM
Citation
 Cook, L; Ternai, B; Ghosh, P Inhibition of human sputum elastase by substituted 2-pyrones. J Med Chem 30:1017-23 (1987) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50024649
Synonyms:
2-Hydroxy-3-(4-methoxy-6-oxo-6H-pyran-2-yl)-acrylic acid ethyl ester | CHEMBL7738
Type:
Small organic molecule
Emp. Form.:
C11H12O6
Mol. Mass.:
240.2094
SMILES:
CCOC(=O)C(=O)Cc1cc(OC)cc(=O)o1
Structure:
Search PDB for entries with ligand similarity: