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Target
Glycine receptor subunit beta
Ligand
BDBM50464260
Substrate
n/a
Meas. Tech.
ChEMBL_1780482 (CHEMBL4251999)
EC50
3100±n/a nM
Citation
 Chakka, N; Andrews, KL; Berry, LM; Bregman, H; Gunaydin, H; Huang, L; Guzman-Perez, A; Plant, MH; Simard, JR; Gingras, J; DiMauro, EF Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators. Eur J Med Chem 137:63-75 (2017) [PubMed]  Article 
Target
Name:
Glycine receptor subunit beta
Synonyms:
GLRB | GLRB_HUMAN | Glycine receptor 58 kDa subunit | Glycine receptor alpha-3/beta | Glycine receptor subunit beta
Type:
PROTEIN
Mol. Mass.:
56135.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117714
Residue:
497
Sequence:
MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL
  
Inhibitor
Name:
BDBM50464260
Synonyms:
CHEMBL4282176
Type:
Small organic molecule
Emp. Form.:
C18H19NO6S
Mol. Mass.:
377.412
SMILES:
COc1ccc(C)cc1OC1CN(C1)S(=O)(=O)c1ccc2OCOc2c1
Structure:
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