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Target
Proteasome subunit beta type-9
Ligand
BDBM50007203
Substrate
n/a
Meas. Tech.
ChEMBL_1783551 (CHEMBL4255068)
IC50
590±n/a nM
Citation
 Richy, N; Sarraf, D; Maréchal, X; Janmamode, N; Le Guével, R; Genin, E; Reboud-Ravaux, M; Vidal, J Structure-based design of human immuno- and constitutive proteasomes inhibitors. Eur J Med Chem 145:570-587 (2018) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-9
Synonyms:
LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein
Type:
PROTEIN
Mol. Mass.:
23256.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
219
Sequence:
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
  
Inhibitor
Name:
BDBM50007203
Synonyms:
CHEMBL3237875
Type:
Small organic molecule
Emp. Form.:
C31H40N4O7
Mol. Mass.:
580.6719
SMILES:
COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1 |r|
Structure:
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