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Target
Estradiol 17-beta-dehydrogenase 2
Ligand
BDBM50466018
Substrate
n/a
Meas. Tech.
ChEMBL_1789617 (CHEMBL4261351)
IC50
89±n/a nM
Citation
 Siebenbuerger, L; Hernandez-Olmos, V; Abdelsamie, AS; Frotscher, M; van Koppen, CJ; Marchais-Oberwinkler, S; Scheuer, C; Laschke, MW; Menger, MD; Boerger, C; Hartmann, RW Highly Potent 17?-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy. J Med Chem 61:10724-10738 (2018) [PubMed]  Article 
Target
Name:
Estradiol 17-beta-dehydrogenase 2
Synonyms:
17-beta-HSD 2 | 17-beta-hydroxysteroid dehydrogenase type 2 | DHB2_MOUSE | Edh17b2 | Hsd17b2 | Testosterone 17-beta-dehydrogenase
Type:
PROTEIN
Mol. Mass.:
41847.95
Organism:
Mus musculus
Description:
ChEMBL_104366
Residue:
381
Sequence:
MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH
  
Inhibitor
Name:
BDBM50466018
Synonyms:
CHEMBL4283851
Type:
Small organic molecule
Emp. Form.:
C18H9Cl2F3O3S
Mol. Mass.:
433.228
SMILES:
COc1c(Cl)cc(cc1Cl)-c1ccc(s1)C(=O)c1cc(F)c(F)c(O)c1F
Structure:
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