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Target
Sodium- and chloride-dependent GABA transporter 3
Ligand
BDBM50466782
Substrate
n/a
Meas. Tech.
ChEMBL_1793942 (CHEMBL4265861)
IC50
3548±n/a nM
Citation
 Tóth, K; Höfner, G; Wanner, KT Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors. Bioorg Med Chem 26:5944-5961 (2018) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 3
Synonyms:
GABA transporter | GAT-3 | Gabt3 | Gabt4 | Gat-4 | Gat3 | Gat4 | S6A11_MOUSE | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Sodium- and chloride-dependent GABA transporter 4 | Solute carrier family 6 member 11
Type:
PROTEIN
Mol. Mass.:
69962.73
Organism:
Mus musculus
Description:
ChEMBL_1460090
Residue:
627
Sequence:
MTAEQALPLGNGKAAEEARGSETLGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRTVTVNDCEAKVKGDGTISAITEKETHF
  
Inhibitor
Name:
BDBM50466782
Synonyms:
CHEMBL4288852
Type:
Small organic molecule
Emp. Form.:
C32H33NO4S
Mol. Mass.:
527.674
SMILES:
COc1ccc(cc1)C(\C=C\CN1CCCC(C1)C(O)=O)(c1ccc(OC)cc1)c1ccc2sccc2c1
Structure:
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