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Target
Plasminogen
Ligand
BDBM50467212
Substrate
n/a
Meas. Tech.
ChEMBL_1795379 (CHEMBL4267496)
IC50
1600±n/a nM
Citation
 Islam, I; Yuan, S; West, CW; Adler, M; Bothe, U; Bryant, J; Chang, Z; Chu, K; Emayan, K; Gualtieri, G; Ho, E; Light, D; Mallari, C; Morser, J; Phillips, G; Schaefer, C; Sukovich, D; Whitlow, M; Chen, D; Buckman, BO Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett 28:3372-3375 (2018) [PubMed]  Article 
Target
Name:
Plasminogen
Synonyms:
Activation peptide | Angiostatin | PLMN_MOUSE | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B | Plg
Type:
PROTEIN
Mol. Mass.:
90808.03
Organism:
Mus musculus
Description:
ChEMBL_452527
Residue:
812
Sequence:
MDHKEVILLFLLLLKPGQGDSLDGYISTQGASLFSLTKKQLAAGGVSDCLAKCEGETDFVCRSFQYHSKEQQCVIMAENSKTSSIIRMRDVILFEKRVYLSECKTGIGNGYRGTMSRTKSGVACQKWGATFPHVPNYSPSTHPNEGLEENYCRNPDNDEQGPWCYTTDPDKRYDYCNIPECEEECMYCSGEKYEGKISKTMSGLDCQAWDSQSPHAHGYIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPTKRWEYCDIPRCTTPPPPPSPTYQCLKGRGENYRGTVSVTVSGKTCQRWSEQTPHRHNRTPENFPCKNLEENYCRNPDGETAPWCYTTDSQLRWEYCEIPSCESSASPDQSDSSVPPEEQTPVVQECYQSDGQSYRGTSSTTITGKKCQSWAAMFPHRHSKTPENFPDAGLEMNYCRNPDGDKGPWCYTTDPSVRWEYCNLKRCSETGGSVVELPTVSQEPSGPSDSETDCMYGNGKDYRGKTAVTAAGTPCQGWAAQEPHRHSIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTTNPRKLYDYCDIPLCASASSFECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTRFTGQHFCGGTLIAPEWVLTAAHCLEKSSRPEFYKVILGAHEEYIRGLDVQEISVAKLILEPNNRDIALLKLSRPATITDKVIPACLPSPNYMVADRTICYITGWGETQGTFGAGRLKEAQLPVIENKVCNRVEYLNNRVKSTELCAGQLAGGVDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVDWIEREMRNN
  
Inhibitor
Name:
BDBM50467212
Synonyms:
CHEMBL4285028
Type:
Small organic molecule
Emp. Form.:
C23H22F2N2O4
Mol. Mass.:
428.4286
SMILES:
CC[C@@H](Oc1nc(Oc2cc(C)cc(c2)-c2cccc(CN)c2)c(F)cc1F)C(O)=O |r|
Structure:
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