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Target
Protein kinase C zeta type
Ligand
BDBM50468260
Substrate
n/a
Meas. Tech.
ChEMBL_1798999 (CHEMBL4271291)
IC50
1.000000±n/a nM
Citation
 Maruta, H; Ahn, MR From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. Eur J Med Chem 142:229-243 (2017) [PubMed]  Article 
Target
Name:
Protein kinase C zeta type
Synonyms:
KPCZ_RAT | Pkcz | Prkcz | Protein kinase C (PKC) | Protein kinase C zeta type | nPKC-zeta
Type:
PROTEIN
Mol. Mass.:
67722.31
Organism:
Rattus norvegicus
Description:
ChEMBL_104731
Residue:
592
Sequence:
MPSRTDPKMDRSGGRVRLKAHYGGDILITSVDPTTTFQDLCEEVRDMCGLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLACQGRDEVLIIHVFPSIPEQPGMPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHVLVPLTCRRHMDSVMPSQEPPVDDKNDGVDLPSEETDGIAYISSSRKHDNIKDDSEDLKPVIDGVDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSAEESV
  
Inhibitor
Name:
BDBM50468260
Synonyms:
CHEMBL4282837
Type:
Small organic molecule
Emp. Form.:
C28H26N4O5
Mol. Mass.:
498.5298
SMILES:
[H][C@]12C[C@@H](NC)[C@@H](OC)[C@](C)(O1)n1c3ccc(O)cc3c3c4CNC(=O)c4c4c5cc(O)ccc5n2c4c13 |r|
Structure:
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