Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase XIAP
Ligand
BDBM62527
Substrate
n/a
Meas. Tech.
ChEMBL_1800813 (CHEMBL4273105)
IC50
1540±n/a nM
Citation
 Channar, PA; Afzal, S; Ejaz, SA; Saeed, A; Larik, FA; Mahesar, PA; Lecka, J; Sévigny, J; Erben, MF; Iqbal, J Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile. Eur J Med Chem 156:461-478 (2018) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase XIAP
Synonyms:
API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
56685.27
Organism:
Homo sapiens (Human)
Description:
P98170
Residue:
497
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
  
Inhibitor
Name:
BDBM62527
Synonyms:
(3,5-Dimethyl-pyrazol-1-yl)-pyridin-4-yl-methanone | (3,5-dimethyl-1-pyrazolyl)-pyridin-4-ylmethanone | (3,5-dimethylpyrazol-1-yl)-(4-pyridyl)methanone | (3,5-dimethylpyrazol-1-yl)-pyridin-4-yl-methanone | (3,5-dimethylpyrazol-1-yl)-pyridin-4-ylmethanone | MLS000029407 | SMR000012020 | cid_645025
Type:
Small organic molecule
Emp. Form.:
C11H11N3O
Mol. Mass.:
201.2245
SMILES:
Cc1cc(C)n(n1)C(=O)c1ccncc1
Structure:
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