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Target
Guanine nucleotide-binding protein subunit alpha-11
Ligand
BDBM50468902
Substrate
n/a
Meas. Tech.
ChEMBL_1801541 (CHEMBL4273833)
IC50
150±n/a nM
Citation
 Zhang, H; Nielsen, AL; Boesgaard, MW; Harpsøe, K; Daly, NL; Xiong, XF; Underwood, CR; Haugaard-Kedström, LM; Bräuner-Osborne, H; Gloriam, DE; Strømgaard, K Structure-activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. Eur J Med Chem 156:847-860 (2018) [PubMed]  Article 
Target
Name:
Guanine nucleotide-binding protein subunit alpha-11
Synonyms:
G alpha-11 | G-protein subunit alpha-11 | GA11 | GNA11 | GNA11_HUMAN | Guanine nucleotide-binding protein G(y) subunit alpha | Guanine nucleotide-binding protein subunit alpha-11
Type:
PROTEIN
Mol. Mass.:
42118.31
Organism:
Homo sapiens
Description:
ChEMBL_117985
Residue:
359
Sequence:
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
  
Inhibitor
Name:
BDBM50468902
Synonyms:
CHEMBL4288881
Type:
Small organic molecule
Emp. Form.:
C46H69N7O15
Mol. Mass.:
960.078
SMILES:
CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C |r|
Structure:
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