Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50026389
Substrate
n/a
Meas. Tech.
ChEBML_54600
Ki
0.004000±n/a nM
Citation
 Piper, JR; McCaleb, GS; Montgomery, JA; Schmid, FA; Sirotnak, FM Syntheses and evaluation as antifolates of MTX analogues derived from 2, omega-diaminoalkanoic acids. J Med Chem 28:1016-25 (1985) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MOUSE | Dhfr
Type:
Enzyme
Mol. Mass.:
21608.82
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50026389
Synonyms:
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-ureido-butyric acid | CHEMBL7684
Type:
Small organic molecule
Emp. Form.:
C20H24N10O4
Mol. Mass.:
468.4692
SMILES:
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCNC(N)=O)C(O)=O
Structure:
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