Reaction Details Report a problem with these data
Target
FYVE, RhoGEF and PH domain-containing protein 1
Ligand
BDBM50026671
Substrate
n/a
Meas. Tech.
ChEBML_212947
Ki
230000±n/a nM
Citation
 Lim, MI; Moyer, JD; Cysyk, RI; Marquez, VE Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase. J Med Chem 27:1536-8 (1985) [PubMed]  Article 
Target
Name:
FYVE, RhoGEF and PH domain-containing protein 1
Synonyms:
FGD1 | FGD1_HUMAN | FGDY | Rho/Rac guanine nucleotide exchange factor | ZFYVE3
Type:
PROTEIN
Mol. Mass.:
106560.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_212947
Residue:
961
Sequence:
MHGHRAPGGAGPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQFVGPSDTSLGAAPGHRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPGQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPEPVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEEAPVAALGATAEPPESPQTRDKT
  
Inhibitor
Name:
BDBM50026671
Synonyms:
1-(4,5-Dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-4-hydroxy-1H-pyrimidin-2-one | CHEMBL1966557
Type:
Small organic molecule
Emp. Form.:
C10H12N2O5
Mol. Mass.:
240.2127
SMILES:
OCC1=C[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |t:2|
Structure:
Search PDB for entries with ligand similarity: