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Target
Thymidine kinase
Ligand
BDBM50472224
Substrate
n/a
Meas. Tech.
ChEMBL_61076 (CHEMBL674916)
EC50
214000±n/a nM
Citation
 Holý, A; Günter, J; Dvoráková, H; Masojídková, M; Andrei, G; Snoeck, R; Balzarini, J; De Clercq, E Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. J Med Chem 42:2064-86 (1999) [PubMed]  Article 
Target
Name:
Thymidine kinase
Synonyms:
KITH_HHV1S | TK | Thymidine kinase | UL23
Type:
PROTEIN
Mol. Mass.:
40883.42
Organism:
Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1)
Description:
ChEMBL_213
Residue:
376
Sequence:
MASYPGHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMIQTHVTTPGSIPTICDLARTFAREMGEAN
  
Inhibitor
Name:
BDBM50472224
Synonyms:
CHEMBL303767
Type:
Small organic molecule
Emp. Form.:
C14H25N6O4P
Mol. Mass.:
372.3599
SMILES:
CC(C)OP(=O)(COCCn1cnc2c(N)nc(N)nc12)OC(C)C
Structure:
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